THE ROLE OF EOSINOPHILS IN ASTHMA 7 eosinophilopoiesis and rate of egress from the bone marrow. Eosinophils usually account for less than 7% of the circulating leukocytes. Asthma is a common chronic condition with an economic burden of almost $56 billion annually in the US. Researchers examined records for patients who were hospitalized for asthma-related complications and had a blood eosinophil count taken the year prior to the hospitalization. J Asthma. However, certain genetic variations may stimulate higher eosinophil levels and severe asthma. Other immune system disorders also can contribute to ongoing (chronic) inflammation. In such cases, eosinophil levels may stay elevated even between asthma episodes. The purpose of this study was to determine whether healthcare resource use and expenditures vary by eosinophil level among patients with asthma.
For example, eosinophils play a key role in the symptoms of asthma and allergies, such as hay fever. We investi The eosinophil recruitment results from the complex mechanisms that involve interaction of adhe- sion molecules on the eosinophils with counter ligands on endothelial cells, extracellular matrix proteins and other tissue structures (15).
Ortega H(1), Llanos JP(2), Lafeuille MH(3), Duh MS(3), Germain G(3), Lejeune D(3), Sama S(4), Bell C(2), Hahn B(2).
A high blood eosinophil count increased the risk for a second asthma-related hospitalization within 1 year, according to a study published in PloS One. This makes asthma that tougher to control, even with corticosteroids. Biologic markers like blood eosinophils, that help predict the risk of exacerbation could help guide more optimal treatment plans and reduce cost.
While not approved for eosinophilic asthma, omalizumab has shown positive benefit in patients with eosinophilic asthma, with greater success in patients with higher eosinophil counts. BACKGROUND: Elevated sputum eosinophil counts predict asthma exacerbations and responsiveness to inhaled corticosteroids but are impractical to measure in primary care. Additionally, approximately 60% of patients with baseline blood eosinophil counts ≥150–<300 cells/μL receiving placebo had at least 1 post-baseline eosinophil count ≥300 cells/μL, according to the study. 2019 Aug;56(8):808-815. doi: 10.1080/02770903.2018.1502301. Approximately one-third had at least 1 post-baseline blood eosinophil count ≥300 cells/μL. 1. Other immune system disorders also can contribute to ongoing (chronic) inflammation. Effects of systemic corticosteroids on blood eosinophil counts in asthma: real-world data. Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 0.5 × 10 9 /l (500/μL). A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is …
Epub 2018 Oct 16.
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